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Introducing the Landmark Twentieth Edition of the Global Icon of Internal Medicine The definitive guide to internal medicine is more essential than ever with the latest in disease mechanisms, updated clinical trial results and recommended guidelines, state-of-the art radiographic images, therapeutic approaches and specific treatments, hundreds of demonstrative full-color drawings, and practical clinical decision trees and algorithms. Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, »Harrison's Principles of Internal Medicine« gives you the informational foundation you need to provide the best patient care possible.

Essential for practice and education, the landmark 20th Edition features: Thoroughly revised content — covering the many new breakthroughs and advances in clinical medicine that have occurred since the last edition of Harrison's.

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Chapters on acute and chronic hepatitis, management of diabetes, immune-based therapies in cancer, multiple sclerosis, cardiovascular disease, HIV, and many more, deliver the very latest information on disease mechanisms, diagnostic options, and the specific treatment guidance you need to provide optimal patient care. State-of-the-art coverage of disease mechanisms: Harrison's focuses on pathophysiology with rigor, and with the goal of linking disease mechanisms to treatments.

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Improved understanding of how diseases develop and progress not only promotes better decision-making and higher value care, but also makes for fascinating reading and improved retention. Harrison's summarizes important new basic science developments, such as the role of mitochondria in programmed and necrotic cell death, the immune system's role in cancer development and treatment, the impact of telomere shortening in the aging and disease processes, and the role of the microbiome in health and disease.

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All-new sections covering a wide range of new and emerging areas of vital interest to all healthcare professionals. New sections include: Sex and Gender-based Issues in Medicine; Obesity, Diabetes Mellitus, and Metabolic Syndrome; and Consultative Medicine?

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Plus, a new Part covering cutting-edge topics in research and clinical medicine includes great new chapters on the role of Epigenetics in Health and Disease, Behavioral Strategies to Improve Health, Genomics and Infectious Diseases, Emerging Neuro-Therapeutic Technologies, and Telomere Function in Health and Disease, and Network System Medicine.

Important and timely new chapters such as Promoting Good Health, LGBT Health, Systems of Healthcare, Approach to Medical Consultation, Pharmacogenomics, Antimicrobial Resistance, Worldwide Changes in Patterns of Infectious Diseases, Neuromyelitis Optica, and more offer the very latest, definitive perspectives on must-know topics in medical education and practice.

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Updated clinical guidelines, expert opinions, and treatment approaches from world-renowned editors and authors contribute to the accuracy and immediacy of the text material and present a clear blueprint for optimizing patient outcomes. Presented in two volumes: Volume 1 is devoted to cardinal manifestations of disease and approach to differential diagnosis Volume 2 covers specific diseases and disorders J. Larry Jameson, MD, PhD; Robert G.

Dunlop Professor of Medicine; Dean, Raymond and Ruth Perelman School of Medicine; Executive Vice President, University of Mark rosenfeld multiple dating for the Health System, Philadelphia, Pennsylvania Anthony S. Fauci, MD; Chief, Laboratory of Immunoregulation; Director, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland Dennis L.

Kasper, MD; William Ellery Channing Professor of Medicine and Professor of Microbiology and Immunobiology, Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts Stephen L.

Hauser, MD; Director, UCSF Weill Institute mark rosenfeld multiple dating Neurosciences; Robert A. Fishman Distinguished Professor, Department of Neurology, University of California, San Francisco, San Francisco, California Dan L.

Lloyd-Jones, Kathleen M. McKibbin 3 Decision-Making in Clinical Medicine Daniel B. Mark, John B. Wong 4 Screening and Prevention of Disease Katrina A. Armstrong, Gary J. Martin 5 Health Care Systems in Developed Countries Richard B. Saltman 6 The Safety and Quality of Health Mark rosenfeld multiple dating David W. Bates 7 Racial and Ethnic Disparities in Health Care Joseph R.

Betancourt, Alexander R. Green 8 Ethical Issues in Clinical Medicine Bernard Lo, Christine Grady 9 Palliative and End-of-Life Care Ezekiel J. Emanuel Part 2: Cardinal Manifestations and Presentation of Diseases Section 1: Pain 10 Pain: Pathophysiology and Management James Sich näher kennenlernen französisch. Rathmell, Howard L. Fields 11 Chest Discomfort.

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